H2N2V1, Main, Exploration, bibRecord, 002077

The critical cut-off temperature of avian influenza viruses

Identifieur interne : 002077 ( Main/Exploration ); précédent : 002076; suivant : 002078

The critical cut-off temperature of avian influenza viruses

Auteurs : John W. Mccauley [Royaume-Uni] ; Charles R. Penn [Royaume-Uni]

Source :

Virus Research [ 0168-1702 ] ; 1990.

RBID : ISTEX:4835D1946EF68326ECD413B3DEF3C7DFA9E47E0E

English descriptors

Teeft :
- Afrc institute, Animal health, Avian, Avian influenza virus, Avian influenza viruses, Balanced salt solution, Chick, Critical temperature, Dobson segment, Form plaques, Fowl, Fowl plague, Fowl plague virus, Gene constellation, Genotype, Infectious allantoic fluid, Influenza, Influenza virus, Influenza viruses, Inoculated birds, Maximum temperature, Molecular biology, Nucleotide, Nucleotide sequence, Parental virus, Pathogenicity, Pirbright laboratory, Plaque, Plaque formation, Primary chick embryo fibroblasts, Reassortant viruses, Recombinant, Recombinant viruses, Rott, Same genotype, Scholtissek, Sequencing, Temperature dependence, Virology, Virus, Virus pathogenicity, Vrna.

Abstract

Abstract: We have measured the pathogenicity for 6-week-old chicks of infection by H7 avian influenza viruses. One virus, strain S3 from A/FPV/Rostock/34(H7Nl) showed a temperature sensitive phenotype at 41.5°C and reduced pathogenicity. By analysis of reassortants made between virus S3 and A/FPV/Dobson/27(H7N7), a fully pathogenic virus, two conclusions arise. (1) The critical cut-off temperature for avian influenza virus in 6-week-old chicks is 41.5°.(2) RNA segment 1 of virus S3 is responsible for the lack of pathogenicity in reassortant viruses. Nucleotide sequencing of RNA segment 1 from S3 and its parent, A/FPV/Rostock/34 has revealed a single mutation at nucleotide 1561. This results in a substitution of isoleucine for leucine at amino acid position 512 in the cap-binding protein, PB2.

Url:

https://api.istex.fr/ark:/67375/6H6-6QXVS0TM-V/fulltext.pdf

DOI: 10.1016/0168-1702(90)90064-I

Affiliations:

Royaume-Uni

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: We have measured the pathogenicity for 6-week-old chicks of infection by H7 avian influenza viruses. One virus, strain S3 from A/FPV/Rostock/34(H7Nl) showed a temperature sensitive phenotype at 41.5°C and reduced pathogenicity. By analysis of reassortants made between virus S3 and A/FPV/Dobson/27(H7N7), a fully pathogenic virus, two conclusions arise. (1) The critical cut-off temperature for avian influenza virus in 6-week-old chicks is 41.5°.(2) RNA segment 1 of virus S3 is responsible for the lack of pathogenicity in reassortant viruses. Nucleotide sequencing of RNA segment 1 from S3 and its parent, A/FPV/Rostock/34 has revealed a single mutation at nucleotide 1561. This results in a substitution of isoleucine for leucine at amino acid position 512 in the cap-binding protein, PB2.</div>
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The critical cut-off temperature of avian influenza viruses

The critical cut-off temperature of avian influenza viruses

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri